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Arthritis - Letter: Case Report: Beneficial Response in Chronic Arthritis to D-L Phenylalanine
Letter: Case Report: Beneficial Response in Chronic
Arthritis to D-L Phenylalanine
Robert E. Buckley, M.D.
Journal of
Orthomolecular Medicine Vol. 1, Number 1, 1987
A significant number of chronic pain patients have found pertinent pain
relief when using D-L phenylalanine. While DLPA often has value for chronic pain
disorders it has no value for acute pain. This confirms that chronic and acute
pain use somewhat different mechanisms and pathways as these peripheral
sensations are projected to brain centers involved in the conscious perception
of pain. It is believed that the dextrorotatory phenylalanine which is
relatively inactive biologically is responsible for inhibiting or preventing
metabolic destruction of synaptic endorphine or enkephaline. In that instance
these naturally occurring neurotransmitters will be more effective in blocking
the transmission and perception of pain.
A trial of 750 mgm of this D-L
mixture t.i.d. can be used for a week to check upon the clinical response. If no
response occurs the amount can be doubled for another week to be sure that
enough had been used. When relief has occurred a few patients can reduce the
amount required to maintain this relief. Some can even discontinue its use for
as long as a week before needing to begin its use again.
It is of
interest that this is a "pharmacologic" use of a large dosage of this amino acid
because the biolocally active levorotatory compound is not effective in causing
pain relief. Both versions are easily metabolized and very safe to use in large
doses. However, since we are not using the D-phenylalanine to supplement
intracellular metabolic activity, the D-L phenylalanine amounts to a "non
orthomolecular" use of megadoses of a safe, non-toxic compound.
The
patient is a 50 year old retired man whose major problem involved a toxic
sensitivity to industrial fumes. He was also sensitive to several foods,
particularly wheat, sodium glutamate in Chinese dishes, also alcohol, especially
white wines which could increase his sense of exhaustion. He had chronic
generalized pain in his extremeties and particularly in his lumbar paraspinal
area which was caused by a non-union fracture of a lamella of the fifth lumbar
vertebrae.
The use of D-L phenylalanine, 750 mgm t.i.d. with meals had no
apparent effect for the first 4 days. On awakening the fifth day he realized
that he could roll over to get out of bed without discomfort. He had become so
inured to this level of pain that he did not identify it even to himself as
pain. During this time he was using no alcohol since it would increase his
physical complaints when he felt depressed. Within 2 days he found that the
chronic low level pain in his extremities, especially hands and ankles, had
disappeared. Several days later he had a "special dinner" out with his wife to
celebrate this relief, and had 2 drinks. He had pain in both achilles tendons
and in the tendons of his hands that evening and a return to his lower back pain
the following day. These pains were not so severe as previously, and were
relieved in one day by the continuing use of D-L phenylalanine. He has
subsequently found that the use of alcohol is consistently related to a prompt
recurrence of the tendon pains, and by low back pains on the following day. He
has found that when he increased his physical activity and began to work on
postponed projects that he had acute aches and pains while getting into better
physical condition.
In short, he had a clear relief from chronic tendon
and musculoskeletal pain, with no relief from acute pains, including those which
occur while getting into better condition for increased physical efforts. He was
surprised to find that pain in his achilles and his finger tendons could
consistently recur, even though at decreased intensity, when he drank socially.
The depression which he was experiencing at the start of therapy decreased as he
was able to increase his activity, and he returned to a "normal" level of moods
within a month of beginning to use the phenylalanine. This relief from chronic
pains has continued for over one year. He must maintain dosage at the same level
as when he began its use. If he reduces the amount to 375 mgm t.i.d., or to 750
mgm HS alone, the chronic pains return at a lower level of intensity in three
days. When he uses 750 mgm t.i.d. he can continue a normal activity in comfort
and good spirits.
Robert E. Buckley, M.D.